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Mortality of cerebral venous-sinus thrombosis in a large national sample
Afshin Borhani Haghighi1, Randall C Edgell, Salvador Cruz-Flores
1Souers Stroke Institute, Department of Neurology, St Louis University, 1438 S Grand Boulevard, St Louis, MO 63104, USA.
Background And Purpose:
The purpose of this study was to evaluate the mortality rates associated with cerebral venous-sinus thrombosis in a large national sample.
Methods:
A cohort of patients with cerebral venous-sinus thrombosis was identified from the National Inpatient Sample database for the years 2000 to 2007. According to the International Classification of Diseases, 9th Revision, Clinical Modification codes, cerebral venous-sinus thrombosis is categorized into pyogenic and nonpyogenic groups. Multivariate logistic regression analysis was used to assess covariates associated with hospital mortality.
Results:
Among 3488 patients, the overall mortality rate was 4.39%, which was nonsignificantly higher among the pyogenic group (4.55% versus 3.52%; OR, 0.76; 95% CI, 0.47-1.23). In the pyogenic cerebral venous-sinus thrombosis group, hematologic disorders were the most frequent predisposing condition (16.2%); whereas systemic malignancy followed by hematologic disorders were most common in the nonpyogenic group (14.08% and 10.04%, respectively). Predictors of mortality included age, intracerebral hemorrhage as well as the predisposing conditions of hematologic disorders, systemic malignancy, and central nervous system infection.
Conclusions:
Compared with arterial stroke, CVST harbors a relatively low mortality rate. Death is determined by age, the presence of intracerebral hemorrhage, and certain predisposing conditions.
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