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Updated: May 28, 2026

Static Strength Training Method for Type 2 Diabetic Mice
Published on: March 29, 2024
Creatine supplementation does not augment muscle carnosine content in type 2 diabetic patients
Bruno Gualano1, Rebeca Lugaresi, Vitor de Salles Painelli
1School of Physical Education and Sport, School of Medicine, University of Sao Paulo, Av Mello de Moraes, Sao Paulo, SP, Brazil. gualano@usp.br
Abstract:
We examined whether creatine supplementation affects muscle carnosine content in type 2 diabetic patients. Subjects were randomly assigned to receive either creatine (5 g·day(-1)) or placebo in a double-blind fashion. At baseline and after 12 weeks, carnosine content was evaluated in gastrocnemius and soleus muscles by using a 1H-MRS technique. No changes were found in gastrocnemius (p = 0.81) and soleus (p = 0.85). We concluded that creatine supplementation does not augment muscle carnosine content in type 2 diabetic patients.
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