Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dopamine receptor subtypes: beyond the D1/D2 classification.

P H Andersen1, J A Gingrich, M D Bates

  • 1Novo Nordisk A/S, CNS Division, Bagsvaerd, Denmark.

Trends in Pharmacological Sciences
|June 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neonatal infant EEG bursts are altered by prenatal maternal depression and serotonin selective reuptake inhibitor use.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2019
Same author

The physiological relevance of functional selectivity in dopamine signalling.

International journal of obesity supplements·2016
Same author

Chronic generalized fibrotic skin lesions from disseminated leishmaniasis caused by Leishmania martiniquensis in two patients from northern Thailand infected with HIV.

The British journal of dermatology·2015
Same author

Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice.

Molecular psychiatry·2015
Same author

Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice.

Molecular psychiatry·2015
Same author

Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits.

Neurobiology of disease·2014
Same journal

Targeting developmental reprogramming: hPSC insights for cancer interception.

Trends in pharmacological sciences·2026
Same journal

July 2026 issue first authors.

Trends in pharmacological sciences·2026
Same journal

Chronobiomaterials for circadian-aligned brain therapeutics.

Trends in pharmacological sciences·2026
Same journal

Biosensors for translatable GPCR bias.

Trends in pharmacological sciences·2026
Same journal

ECM stiffness and epigenetics in organ fibrosis.

Trends in pharmacological sciences·2026
Same journal

Which HTT transcript to lower?

Trends in pharmacological sciences·2026
See all related articles

Evidence suggests novel dopamine receptor subtypes beyond the established D1 and D2 classifications. Molecular cloning is expected to confirm these new subtypes, expanding our understanding of dopamine signaling.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Molecular Biology

Background:

  • The current classification of dopamine receptors into D1 and D2 subtypes is widely accepted in neuroscience.
  • However, accumulating pharmacological, biochemical, and behavioral data present challenges to this binary model.
  • Advances in G-protein-coupled receptor research highlight molecular heterogeneity as a source of functional diversity.

Purpose of the Study:

  • To review the evidence supporting the existence of previously unrecognized dopamine receptor subtypes.
  • To discuss the implications of this receptor heterogeneity for understanding dopamine system function.
  • To predict the role of molecular cloning in confirming novel dopamine receptor subtypes.

Main Methods:

  • Review of pharmacological data characterizing dopamine receptor interactions.

Related Experiment Videos

  • Analysis of biochemical studies investigating dopamine receptor function.
  • Examination of behavioral studies linked to dopamine receptor activity.
  • Consideration of recent molecular cloning findings for G-protein-coupled receptors.

    • Main Results:

    • Pharmacological, biochemical, and behavioral data are increasingly inconsistent with only two dopamine receptor subtypes.
    • Heterogeneity in receptor characteristics often points to novel molecular subtypes.
    • Evidence suggests the presence of several new subtypes for both D1 and D2 dopamine receptors.

    Conclusions:

    • The established D1/D2 dopamine receptor classification may be incomplete.
    • Novel dopamine receptor subtypes likely exist and contribute to receptor diversity.
    • Molecular cloning is anticipated to provide definitive confirmation of these new subtypes in the near future.