Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

VIP neurons in the cerebral cortex.

P J Magistretti1

  • 1Institute of Physiology, Faculty of Medicine, University of Lausanne, Switzerland.

Trends in Pharmacological Sciences
|June 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epileptiform activity in brain organoids derived from patient with Glucose Transporter 1 Deficiency Syndrome.

Frontiers in neuroscience·2024
Same author

Ultrastructural Evidence for a Role of Astrocytes and Glycogen-Derived Lactate in Learning-Dependent Synaptic Stabilization.

Cerebral cortex (New York, N.Y. : 1991)·2019
Same author

Dual action of L-Lactate on the activity of NR2B-containing NMDA receptors: from potentiation to neuroprotection.

Scientific reports·2018
Same author

Protein targeting to glycogen is a master regulator of glycogen synthesis in astrocytes.

IBRO reports·2018
Same author

Peripheral administration of lactate produces antidepressant-like effects.

Molecular psychiatry·2016
Same author

Peripheral administration of lactate produces antidepressant-like effects.

Molecular psychiatry·2016
Same journal

Engineering cells for solid tumor therapy.

Trends in pharmacological sciences·2026
Same journal

Targeting developmental reprogramming: hPSC insights for cancer interception.

Trends in pharmacological sciences·2026
Same journal

July 2026 issue first authors.

Trends in pharmacological sciences·2026
Same journal

Chronobiomaterials for circadian-aligned brain therapeutics.

Trends in pharmacological sciences·2026
Same journal

Biosensors for translatable GPCR bias.

Trends in pharmacological sciences·2026
Same journal

ECM stiffness and epigenetics in organ fibrosis.

Trends in pharmacological sciences·2026
See all related articles

Vasoactive intestinal peptide (VIP) neurons in the neocortex regulate local metabolism by influencing blood flow and energy production. These neurons release VIP, impacting cAMP signaling and stimulating glycogenolysis.

Area of Science:

  • Neuroscience
  • Cellular Biology
  • Neurophysiology

Background:

  • Vasoactive intestinal peptide (VIP) is released by intrinsic neurons in the neocortex.
  • These VIP-containing neurons are of the bipolar type.
  • VIP release mechanisms involve calcium (Ca2+) and lipoxygenase metabolites.

Purpose of the Study:

  • To review the role of VIP neurons in the local regulation of cerebral cortex metabolism.
  • To explore how VIP neurons influence cortical blood flow and energy metabolism.

Main Methods:

  • Review of existing evidence on VIP neuron function.
  • Analysis of VIP receptor signaling pathways.
  • Examination of VIP's effects on glycogenolysis and cortical blood flow.

Related Experiment Videos

Main Results:

  • VIP neurons are intrinsic bipolar neurons.
  • VIP release is dependent on Ca2+ and lipoxygenase metabolites.
  • VIP receptors activate cAMP-generating systems, amplified by neurotransmitters like noradrenaline, histamine, and GABA.
  • VIP neurons stimulate glycogenolysis and alter cortical blood flow.

Conclusions:

  • VIP neurons play a significant role in the local metabolic regulation of the cerebral cortex.
  • VIP's actions on metabolism are mediated through cAMP signaling and influence on vascular and energy pathways.