Related Experiment Video

Updated: May 28, 2026

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

Prevalence and prognostic implications of pre-diabetic state in patients with heart failure

Yuya Matsue1, Makoto Suzuki, Rena Nakamura

  • 1Department of Medicine, Kameda Medical Center, Chiba, Japan. yuyam@kameda.jp

Circulation Journal : Official Journal of the Japanese Circulation Society
|October 20, 2011
PubMed

Insights

Pre-diabetic states like impaired glucose tolerance (IGT) and diabetes mellitus (DM) worsen outcomes for heart failure (HF) patients. Screening for these conditions using oral glucose tolerance tests (OGTT) can help identify high-risk individuals.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Disorders

Background:

  • Diabetes mellitus (DM) is a known risk factor for poor prognosis in heart failure (HF) patients.
  • The prognostic impact and prevalence of pre-diabetic states in HF are not well understood.

Purpose of the Study:

  • To investigate the prevalence and prognostic significance of glucose metabolism abnormalities, including pre-diabetes, in patients with heart failure.
  • To assess the association between different glucose tolerance categories and major adverse cardiac and cerebrovascular events (MACCE) in HF patients.

Main Methods:

  • A prospective study included 136 consecutive HF patients without previously diagnosed DM.
  • The 75-g oral glucose tolerance test (OGTT) classified patients into normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and newly diagnosed DM groups.
  • Major adverse cardiac and cerebrovascular events (MACCE) were monitored during follow-up.

Main Results:

  • Of 94 patients without known DM, 37.2% had NGT, 9.6% had IFG, 39.4% had IGT, and 13.8% were newly diagnosed with DM.
  • Patients with DM or IGT showed significantly lower MACCE-free rates compared to NGT patients (P=0.006 and P=0.036, respectively).
  • IFG was not significantly associated with increased MACCE risk, but IGT (HR, 4.51; P=0.011) and DM (HR, 4.74; P=0.005) were independent predictors of MACCE.

Conclusions:

  • Impaired glucose tolerance (IGT) and diabetes mellitus (DM) significantly contribute to an adverse prognosis in heart failure patients.
  • Diabetes screening via OGTT is feasible and valuable for risk stratification in HF patients.
Abstract

More Related Videos

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

Related Concept Videos

Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...