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[HBs antigenemia in glomerulonephritis in children]

V V Shparvasser, A B Kanatbaeva, Zh T Temirbekov

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |April 1, 1990
    PubMed

    Insights

    Enzyme immunoassay detected Hepatitis B surface antigen (HBsAg) in 29.1% of acute and 21.4% of chronic glomerulonephritis patients. This sensitive method is recommended for detecting low HBsAg titers in these kidney disease patients.

    Area of Science:

    • Nephrology
    • Virology
    • Immunology

    Background:

    • Glomerulonephritis is a significant kidney disease.
    • Hepatitis B virus (HBV) infection can affect kidney function.
    • Accurate detection of HBsAg is crucial for patient management.

    Purpose of the Study:

    • To evaluate the efficacy of different methods for HBsAg detection in glomerulonephritis patients.
    • To determine the prevalence of HBsAg in patients with acute and chronic glomerulonephritis.
    • To recommend the most sensitive diagnostic approach.

    Main Methods:

    • Comparison of three serological assays: countercurrent immunoelectrophoresis, passive hemagglutination test, and enzyme immunoassay.
    • Analysis of sera from 194 patients diagnosed with glomerulonephritis.
    • Quantification of HBsAg detection rates across different diagnostic methods.

    Main Results:

    • Enzyme immunoassay demonstrated the highest HBsAg detection rate.
    • HBsAg was detected in 29.1% of patients with acute glomerulonephritis.
    • HBsAg was detected in 21.4% of patients with chronic glomerulonephritis.

    Conclusions:

    • Enzyme immunoassay is the most sensitive method for HBsAg detection in glomerulonephritis.
    • This method is particularly valuable for identifying low-titer HBsAg in patient sera.
    • Routine screening with enzyme immunoassay is recommended for glomerulonephritis patients.

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