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Echocardiographic Measurement of Right Ventricular Diastolic Parameters in Mouse

Echocardiographic Measurement of Right Ventricular Diastolic Parameters in Mouse

Published on: April 27, 2019

Ventricular function during exercise in mice and rats.

Heidi L Lujan¹, Hussein Janbaih, Han-Zhong Feng

¹Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology

|October 21, 2011

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This study introduces a new telemetry method for measuring left ventricular (LV) function in conscious mice during rest and exercise. This technique enables detailed cardiac function assessment in freely moving animals, advancing cardiovascular research.

Area of Science:

Cardiovascular physiology
Animal models in research

Background:

Mice are valuable models for studying left ventricular (LV) function.
A need exists for conscious, freely moving mouse models to assess cardiac function.
Existing methods often lack the ability to measure cardiac function in unrestrained, conscious animals.

Purpose of the Study:

To develop and validate a telemetry system for chronic, non-invasive measurement of LV function in conscious mice.
To assess LV function at rest and during exercise in mice using this new method.
To compare mouse responses to those of instrumented rats.

Main Methods:

Implanted telemetry devices (PA-C10) for continuous LV pressure recording in mice.
Surgical implantation into the intraperitoneal space (transmitter) and LV (pressure sensor).

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Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

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Related Experiment Videos

Last Updated: May 28, 2026

Echocardiographic Measurement of Right Ventricular Diastolic Parameters in Mouse

Echocardiographic Measurement of Right Ventricular Diastolic Parameters in Mouse

Published on: April 27, 2019

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

Recovery period, acclimatization to laboratory and treadmill, followed by rest and graded exercise testing.

Main Results:

Successfully demonstrated serial assessment of ventricular function during exercise in conscious mice.
Provided reference data by comparing responses in mice to identically instrumented conscious rats.
Established a reliable method for nontethered recordings of pulsatile LV pressure.

Conclusions:

The developed telemetry methodology allows for the first time serial assessment of cardiac function in conscious, exercising mice.
This technique offers a valuable tool for advancing cardiovascular research and understanding LV function.
The method is adaptable for further studies in cardiovascular physiology and disease models.