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Enzyme-linked Receptors

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...

Enzyme-linked Receptors

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...

Coupled Reactions

Coupled Reactions

Cellular processes such as building and breaking down complex molecules occur through stepwise chemical reactions. Some of these chemical reactions are spontaneous and release energy, whereas others require energy to proceed. Cells often couple the energy-releasing reaction with the energy-requiring one to carry out important cell functions.
Energy in adenosine triphosphate or ATP molecules is easily accessible to do work. ATP powers the majority of energy-requiring cellular reactions. Cells...

Reaction Mechanisms

Reaction Mechanisms

Chemical reactions often occur in a stepwise fashion, involving two or more distinct reactions taking place in a sequence. A balanced equation indicates the reacting species and the product species, but it reveals no details about how the reaction occurs at the molecular level. The reaction mechanism (or reaction path) provides details regarding the precise, step-by-step process by which a reaction occurs.
For instance, the decomposition of ozone appears to follow a mechanism with two steps:

Introduction to Chemical Reactions

Introduction to Chemical Reactions

All chemical reactions begin with a reactant, the general term for one or more substances entering the reaction. Sodium and chloride ions, for example, are the reactants in the production of table salt. One or more substances produced by a chemical reaction are called the product. Chemical reactions follow the law of conservation of mass, which means that matter cannot be created nor destroyed in a chemical reaction. The components of the reactants—the number of atoms and the elements—are all...

Transducer Mechanism: Enzyme-Linked Receptors

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:

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Related Experiment Video

Updated: May 28, 2026

A Web Tool for Generating High Quality Machine-readable Biological Pathways

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

The Reactome BioMart.

Robin A Haw¹, David Croft, Christina K Yung

¹Ontario Institute for Cancer Research, Toronto, ON, M5G0A3, Canada.

Database : the Journal of Biological Databases and Curation

|October 21, 2011

Summary

This summary is machine-generated.

Reactome is an open-source database detailing biological reactions and pathways. It offers tools for data analysis and pathway exploration, aiding researchers in integrating diverse biological information.

Related Experiment Videos

Last Updated: May 28, 2026

A Web Tool for Generating High Quality Machine-readable Biological Pathways

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

Area of Science:

Biochemistry
Systems Biology
Bioinformatics

Background:

Biological pathway databases are crucial for understanding cellular processes.
Expert curation and manual review ensure data accuracy in biological pathway resources.
Integrating diverse data sources is essential for comprehensive biological analysis.

Purpose of the Study:

To present Reactome, an open-source, curated database of biological reactions and pathways.
To highlight the utility of Reactome's web interface and data analysis tools.
To introduce the Reactome BioMart for integrated querying and data analysis.

Main Methods:

Manual curation and expert review of biological reactions and pathways.
Development of an intuitive web-based user interface for pathway knowledge access.
Integration of data aggregation capabilities within the Reactome BioMart.

Main Results:

Reactome provides a comprehensive, peer-reviewed resource for biological pathways.
The platform offers a suite of data analysis tools for pathway exploration.
Reactome BioMart enables integrated queries across multiple data sources.

Conclusions:

Reactome serves as a valuable, open-source resource for biological pathway research.
The database facilitates the integration of experimental and computational findings.
Reactome empowers biologists and bioinformaticians with advanced data analysis capabilities.