Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 28, 2026

Single-port Non-liposuction Endoscopic Axillary Lymph Node Dissection in Breast Cancer Surgery
11:49

Single-port Non-liposuction Endoscopic Axillary Lymph Node Dissection in Breast Cancer Surgery

Published on: April 3, 2026

Positive axillary sentinel lymph node: is axillary dissection always necessary?

Viviana Galimberti1, Camelia Chifu, Suanly Rodriguez Perez

  • 1Division ofSenology, European Institute of Oncology, Milan, Italy. viviana.galimberti@ieo.it

Breast (Edinburgh, Scotland)
|October 22, 2011
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pre-Pectoral Breast Reconstruction after Mastectomy: Current Evidence, Knowledge Gaps, and Rationale for the I-PREPARE EUBREAST-11R Trial.

Breast care (Basel, Switzerland)·2026
Same author

Translating CLEOPATRA into routine practice: National treatment patterns and survival for patients with HER2-positive metastatic breast cancer.

Breast (Edinburgh, Scotland)·2026
Same author

Association between lifestyle and risk of early-onset cancer: Evidence from the European Prospective Investigation into Cancer and Nutrition and the UK Biobank.

European journal of cancer (Oxford, England : 1990)·2026
Same author

Glycosyltransferases as Oncogenic Drivers: Lessons from Cancer Genome Mining.

DNA and cell biology·2026
Same author

Learning and deskilling effects of artificial intelligence in colonoscopy among endoscopists with different levels of experience: a pragmatic, prospective trial.

Endoscopy·2026
Same author

Twenty-Three-Year Benefits of Sigmoidoscopy Screening for Colorectal Cancer : A Randomized Trial.

Annals of internal medicine·2026

Foregoing axillary dissection (AD) for early breast cancer patients with minimal sentinel node (SN) involvement is supported by evidence. This approach shows high survival and low recurrence rates, aligning with clinical practice trends.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Breast Cancer Research

Background:

  • Growing interest in omitting axillary dissection (AD) for early breast cancer with positive sentinel nodes (SN), especially with minimal tumor burden (micrometastases or isolated tumor cells).
  • Current clinical practice appears to precede definitive evidence, with data suggesting AD is underutilized in cases of positive SN.
  • Several clinical trials (IBCSG 23-01, ASCOG Z0011, EORTC AMAROS) are investigating this issue.

Purpose of the Study:

  • To evaluate the safety and efficacy of foregoing AD in early breast cancer patients with micrometastases or isolated tumor cells in the SN.
  • To compare outcomes of patients who did not undergo further axillary treatment after a positive SN versus those who did.

Main Methods:

  • Retrospective analysis of early breast cancer patients with micrometastases or isolated tumor cells in the SN who did not receive further axillary treatment.

More Related Videos

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
07:51

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy

Published on: June 1, 2019

Related Experiment Videos

Last Updated: May 28, 2026

Single-port Non-liposuction Endoscopic Axillary Lymph Node Dissection in Breast Cancer Surgery
11:49

Single-port Non-liposuction Endoscopic Axillary Lymph Node Dissection in Breast Cancer Surgery

Published on: April 3, 2026

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
07:51

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy

Published on: June 1, 2019

  • Review of interim results from the ASCOG Z0011 trial, comparing locoregional and regional recurrence rates between patients with positive SN who underwent AD versus those who did not.

    • Main Results:

    • The ASCOG Z0011 interim analysis showed no significant difference in locoregional or regional recurrence between patients with positive SN who received AD and those who did not, after 6.3 years of follow-up.
    • The retrospective study found high five-year survival rates and a low cumulative incidence of axillary recurrence in patients foregoing AD with minimal SN involvement.
    • These findings support the practice of omitting AD in select early breast cancer cases with limited SN metastasis.

    Conclusions:

    • Foregoing axillary dissection in early breast cancer patients with minimal sentinel node involvement (micrometastases or isolated tumor cells) is a viable approach, supported by current evidence and retrospective data.
    • High survival rates and low axillary recurrence incidence justify the increasing clinical adoption of this strategy.
    • Further research, including ancillary analyses of ongoing trials like IBCSG 23-01 and AMAROS, is needed to identify patients at high risk for overt axillary disease who may benefit from elective AD.