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Related Concept Videos

Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
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Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
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Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

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In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

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Published on: August 24, 2013

Lay representations of genetic disease, and predictive testing.

B J Henderson1, B T Maguire

  • 1School of Psychology, University of Wales, Bangor, UK.

Journal of Health Psychology
|October 25, 2011
PubMed
Summary

Lay people have limited understanding of genetic disease and predictive genetic testing, often focusing on childhood conditions and expressing ethical concerns. More accessible information is needed for informed decision-making regarding genetic testing.

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Published on: February 23, 2011

Area of Science:

  • Human Genetics
  • Medical Sociology
  • Bioethics

Background:

  • Advances in human genetics identify genes for familial cancer and heart disease, leading to predictive genetic testing offers for at-risk individuals.
  • Understanding lay beliefs about genetics is crucial for supporting informed decision-making regarding predictive genetic testing.

Purpose of the Study:

  • To examine lay people's illness representations of genetic disease and their understanding of predictive genetic testing.
  • To identify information needs for individuals facing genetic testing decisions.

Main Methods:

  • Content analysis of open-ended interviews with 20 educated lay people.
  • Exploration of illness representations and knowledge of genetic disorders and predictive testing.

Main Results:

  • Participants demonstrated limited knowledge of late-onset genetic disorders and predictive testing, with greater familiarity with childhood genetic diseases and prenatal testing.
  • Lack of mention of treatment options suggests a deterministic view of genetic diseases.
  • Consistent concerns were raised regarding the ethics of genetic testing and research.

Conclusions:

  • Educated lay people possess incomplete understanding of predictive genetic testing and its implications.
  • Findings highlight the need for improved provision of information to facilitate informed choices about genetic testing.
  • Addressing ethical concerns is paramount in genetic testing communication.