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Updated: May 28, 2026
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The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
Published on: June 1, 2019
[Sentinel lymph node examination in breast carcinoma in situ]
J Mergancová1, Ji Mergancová, I Hrncirová
1Chirurgická klinika, Pardubická krajská nemocnice. jana.mergancova@centrum.cz
Summary
Sentinel lymph node examination in breast carcinoma in situ is crucial for accurate staging and treatment. Specific criteria, such as extensive microcalcifications or preoperative diagnosis, guide this procedure for non-invasive breast cancer.
Area of Science:
- Oncology
- Surgical Pathology
- Diagnostic Imaging
Context:
- Breast carcinoma in situ (non-invasive breast cancer) can present with sentinel lymph node infiltration.
- Accurate staging is essential for appropriate treatment planning in these cases.
Purpose:
- To determine the indication criteria for sentinel lymph node detection in breast carcinoma in situ.
- To evaluate the utility of sentinel lymph node examination in non-invasive breast cancer.
Summary:
- Literature review of 10 studies on ductal carcinoma in situ (DCIS) and 4 on DCIS with microinvasion showed infiltration rates from 0% to 29.4%.
- In a single year, 7 in situ carcinomas were diagnosed; only one lobular carcinoma in situ (LCIS) with microinvasion showed sentinel lymph node infiltration.
- Established criteria include extensive microcalcifications, diffuse involvement requiring mastectomy, palpable resistance, preoperative DCIS diagnosis, or G3 carcinoma in situ on biopsy.
Impact:
- Sentinel lymph node examination can alter disease staging and treatment plans.
- Positive sentinel lymph node findings in presumed in situ disease indicate occult invasive components, necessitating further intervention.
