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Related Concept Videos

Bone Structure01:55

Bone Structure

Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Updated: May 28, 2026

Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry
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Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry

Published on: March 14, 2020

Three-dimensional dynamic bone histomorphometry.

Craig R Slyfield1, Evgeniy V Tkachenko, David L Wilson

  • 1Biomedical Mechanics Laboratories, Sibley School of Mechanical and Aerospace Engineering and Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|October 27, 2011
PubMed
Summary
This summary is machine-generated.

Three-dimensional (3D) histomorphometry reveals that estrogen depletion in ovariectomized rats increases bone remodeling event numbers. This suggests estrogen primarily influences the initiation of bone remodeling, not its progression.

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Area of Science:

  • Biomedical Engineering
  • Orthopedics
  • Cell Biology

Background:

  • Dynamic bone histomorphometry is standard for measuring bone remodeling events.
  • Its 2D nature limits precise quantification of individual event number and size.
  • Osteoporosis research requires advanced methods for detailed bone remodeling analysis.

Purpose of the Study:

  • To develop and apply a novel 3D fluorescence imaging technique for bone histomorphometry.
  • To quantify individual bone resorption and formation events in a rat model of osteoporosis.
  • To elucidate the effects of estrogen depletion on the number and size of bone remodeling events.

Main Methods:

  • Utilized a novel 3D fluorescence imaging technique for bone histomorphometry.
  • Applied the technique to ovariectomized rats, a model for postmenopausal osteoporosis.
  • Quantified resorption cavity and formation event parameters in 3D.

Main Results:

  • Ovariectomy significantly increased the number of resorption cavities and their total volume.
  • No significant differences were observed in resorption cavity surface area, depth, or volume.
  • Bone formation events increased in size due to merging, but mineral apposition rate remained unchanged.
  • Estrogen depletion increased remodeling event initiation but had minimal impact on event progression.

Conclusions:

  • 3D histomorphometry enables precise measurement of individual bone remodeling events.
  • Estrogen depletion in osteoporosis models primarily affects the initiation of bone remodeling.
  • Findings suggest estrogen's role in regulating the origination of basic multicellular units.