Gender differences in the effects of methylphenidate on energy intake in young adults: a preliminary study

The present study examined gender differences in response to methylphenidate (MPH) on energy intake and macronutrient preference. Twelve adults (6 men, 6 women) were given placebo or short-acting MPH (0.5 mg/kg) in a randomized, double blind, placebo-controlled crossover fashion. One hour after drug administration, appetite sensations and the relative reinforcing value of energy-dense snack food were measured, followed immediately by energy intake and macronutrient preference during a buffet lunch. Relative to placebo, men exhibited a significantly greater reduction in energy intake, fat intake, and carbohydrate intake after MPH administration compared with women. Future research is needed to verify these initial findings.