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Related Experiment Video

Updated: May 28, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Estimation of dengue virus IgM persistence using regression analysis.

Harry E Prince¹, Jose L Matud

¹Focus Diagnostics, Inc., Cypress, CA 90630, USA. hprince@focusdx.com

Clinical and Vaccine Immunology : CVI

|October 28, 2011

Summary

Dengue virus IgM antibodies persisted longer in primary infections than secondary infections. Higher initial IgM levels in primary infections, not slower decay, explained this difference in Dengue virus diagnosis.

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Area of Science:

Virology
Immunology
Infectious Diseases

Background:

Dengue virus infection diagnosis relies on detecting IgM antibodies.
Understanding IgM persistence is crucial for accurate diagnostic timing.

Purpose of the Study:

To estimate Dengue virus IgM persistence in primary versus secondary infections.
To determine factors influencing IgM antibody detection duration.

Main Methods:

Follow-up sera from 98 Dengue virus patients (60 primary, 38 secondary) with positive initial IgM indices were analyzed.
Regression analysis correlated IgM index levels with time elapsed since initial sample collection.

Main Results:

IgM antibodies persisted until the diagnostic cut-point (index 1.10) at a median of 179 days post-infection for primary cases.
For secondary Dengue virus infections, IgM antibodies persisted until a median of 139 days.
Higher initial IgM indices in primary infections, not differing decay rates, accounted for the prolonged detection period.

Conclusions:

Dengue virus IgM detection duration differs significantly between primary and secondary infections.
Initial IgM response strength, particularly in primary infections, is a key determinant of diagnostic window length.
These findings have implications for interpreting Dengue virus serological test results and epidemiological studies.