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[Biomechanical research of SOX9, CTGF in bone tendon junction healing]
Zhi-qi Zhu1, Jian-min Jiang, Yan-kui Leng
1Southern Medical Hospital, Southern Medical University, Guangzhou, China.
Aim:
To investigate the biomechanical effect of SOX9, CTGF in bone tendon junction healing.
Methods:
36 adult New Zealand rabbits were randomly divided into A, B and C groups(each group were 12 rab-bits). Group A with SOX9 inject into bone tendon junction;Group B with CTGF inject into bone tendon junction; C group was inject nothing. The animal of three groups were used surgery and all of the animals were faced with biomechanical test after 4 weeks, 8 weeks and 12 weeks; The result were used statistical analysis.
Results:
group A and group B's cross-sectional area were lower than group C during 4 weeks, 12 weeks postoperative; there were statistical difference between each groups ( P < 0. 05). group Aand group B's pulled off load and ultimate tensile stress were higher than group C during 4 weeks, 8 weeks, 12 weeks postoperative, the result were statistical difference between each groups ( P < 0. 05).
Conclusion:
SOX9 and CTGF group can not only promote the early bone ten-don junction healing, But also increased the biomechanical strength of bone tendon junction.
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