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Published on: June 18, 2020
Anti-glomerular basement membrane disease in Auckland
D M Taylor1, M Yehia, I J Simpson
1Department of Renal Medicine, North Shore Hospital, Auckland, New Zealand.
Internal Medicine Journal
|October 29, 2011
Summary
Anti-glomerular basement membrane (GBM) antibody disease is rare, affecting 1.79 per million person-years. Aggressive treatment improved prognosis, but significant morbidity and mortality persist.
Area of Science:
- Nephrology
- Immunology
- Epidemiology
Background:
- Anti-glomerular basement membrane (GBM) antibody disease is a rare autoimmune condition.
- It classically presents with glomerulonephritis and pulmonary hemorrhage.
Purpose of the Study:
- To determine the incidence, clinical features, management, and outcomes of anti-GBM disease.
- Study conducted in Auckland between 1998 and 2008.
Main Methods:
- Retrospective case notes review of patients identified via serology, renal biopsy, or ICD codes.
- Data collected between 1998 and 2008, censored at December 2010.
Main Results:
- 23 cases identified, incidence of 1.79 per million person-years.
- Smoking was significantly associated with anti-GBM disease and respiratory disease.
- Aggressive immunosuppression (cyclophosphamide, corticosteroids) and plasmapheresis were common treatments; 18 patients survived, with varying renal function outcomes.
Conclusions:
- Anti-GBM disease is rare and not overrepresented in indigenous populations.
- Aggressive therapy has improved prognosis, yet significant morbidity and mortality remain.
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