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Chronic urticaria: a comparison of management guidelines
1Service de Dermatologie, Hôpital de l'Archet, 151, route de Saint-Antoine-de-Ginèstre, F-06202, Nice cedex 03, France. ortonne@unice.fr
Expert Opinion on Pharmacotherapy
|November 1, 2011
Summary
Second-generation antihistamines are recommended as a first-line treatment for chronic urticaria. For persistent cases, experts suggest dose escalation or adjunctive therapies, though more research is needed.
Area of Science:
- Dermatology
- Allergy and Immunology
Background:
- Chronic urticaria involves recurrent hives and itching lasting over six weeks.
- It significantly impacts patients' quality of life.
- Effective management strategies are crucial.
Purpose of the Study:
- To review current management guidelines and expert opinions on chronic urticaria.
- To identify evidence-based treatment recommendations.
Main Methods:
- A systematic literature search was performed on Medline from 2000 to 2011.
- Keywords included 'chronic urticaria', 'management guidelines', 'consensus guidelines', and 'expert opinions'.
- Ten relevant guidelines and expert opinions were included in the review.
Main Results:
- All reviewed articles universally agreed on using low-sedating, second-generation antihistamines as first-line therapy.
- For refractory chronic urticaria, recommendations varied, including antihistamine dose escalation or adding other agents.
- Adjunctive treatments mentioned included sedating antihistamines and leukotriene receptor antagonists.
Conclusions:
- Second-generation antihistamines are the established first-line treatment for chronic urticaria.
- Further research is necessary for effective second-line treatments.
- Consistent implementation of clinical guidelines is vital for evidence-based patient care.
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