Related Experiment Video
Updated: May 28, 2026

Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Compound CVT-E002 attenuates allergen-induced airway inflammation and airway hyperresponsiveness, in vivo
Cory Ebeling1, Yingqi Wu, Christopher Skappak
1Pulmonary Research Group, Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Abstract:
Immune modulation has been a sought after means of therapy for atopic diseases. CVT-E002 is an extract derived from North American Ginseng shown to promote T-helper-1-like responses. We determined what effect CVT-E002 could have in a mouse model of atopic asthma. We report that oral CVT-E002 inhibited the development of allergic airway inflammation and airway hyperresponsiveness. This correlated with an increased presence of interferon-γ in the lung, and also increased regulatory T cells and IL-10. The ability of CVT-E002 to induce regulatory T-cell development was also seen in human in vitro co-cultures.
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