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Updated: May 28, 2026

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells

Published on: April 11, 2014

Ascorbic acid deficiency: a case report.

Mishthu Solanki¹, Devinder Kaur Baweja, Sandyadevi S Patil

¹Unit of Pedodontic and Preventive Dentistry, Oral Health Sciences Centre, Postgraduate Institute of Medical and Educational Research, Chandigarh, India. smile_mishi@yahoo.com

Journal of Dentistry for Children (Chicago, Ill.)

|November 2, 2011

Summary

This summary is machine-generated.

Scurvy, a vitamin C deficiency disease, is rare in developed nations but can occur in children with extremely limited diets. Early identification through diet history is crucial for treating this potentially fatal condition.

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Last Updated: May 28, 2026

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells

Published on: April 11, 2014

Area of Science:

Pediatrics
Nutrition
Medical Case Reports

Background:

Scurvy, historically linked to ascorbic acid deficiency, is now rare in developed countries.
It is exceptionally uncommon in children, typically associated with severely restricted diets due to developmental or psychiatric issues.
Classic symptoms include perifollicular petechiae, bruising, gingival bleeding, and bone disease in pediatric cases.

Observation:

A case of scurvy in a 10-year-old boy with developmental delays and extreme food limitations is presented.
The patient exhibited severe bone pain, gingival inflammation, and perifollicular hyperkeratosis.
Dietary history revealed a marked deficiency in vitamin C.

Findings:

Diagnosis was confirmed through clinical presentation and radiographic evidence.
The case highlights the link between highly restricted food choices and the development of scurvy.
Clinical and radiographic findings were consistent with established scurvy presentations.

Implications:

Emphasizes the critical role of detailed dietary history in diagnosing scurvy.
Aims to improve clinician recognition of scurvy in pediatric patients.
Underscores that scurvy, though potentially fatal, is easily treatable with prompt intervention.