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Related Concept Videos

Development of Blood Vessels01:07

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Overview of the Vascular System01:20

Overview of the Vascular System

The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Development of the Heart01:27

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...

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Related Experiment Video

Updated: May 27, 2026

Micropatterning and Assembly of 3D Microvessels
13:05

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

Endothelial development taking shape.

Andrin Wacker1, Holger Gerhardt

  • 1Vascular Patterning Laboratory, Vesalius Research Center, VIB, B-3000 Leuven, Belgium.

Current Opinion in Cell Biology
|November 5, 2011
PubMed
Summary
This summary is machine-generated.

Vascular development, crucial for embryonic growth and adult regeneration, is increasingly understood through cellular-level studies. Advances in imaging and genetic tools reveal endothelial cell behavior and network formation in angiogenesis.

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Related Experiment Videos

Last Updated: May 27, 2026

Micropatterning and Assembly of 3D Microvessels
13:05

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

In Vitro Model of Fetal Human Vessel On-chip to Study Developmental Mechanobiology
09:12

In Vitro Model of Fetal Human Vessel On-chip to Study Developmental Mechanobiology

Published on: July 28, 2023

Generation of Human Blood Vessel Organoids from Pluripotent Stem Cells
09:46

Generation of Human Blood Vessel Organoids from Pluripotent Stem Cells

Published on: January 20, 2023

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Physiology

Background:

  • Blood vessel formation (angiogenesis) is essential for embryonic development, tissue growth, regeneration, and adult diseases.
  • Recent research focuses on molecular mechanisms regulating vascular lumen formation, sprouting, fusion, and pruning.
  • Understanding angiogenesis at the cellular level is key to deciphering complex vascular network development.

Purpose of the Study:

  • To summarize recent advancements in vascular development research.
  • To highlight the role of endothelial cells in angiogenesis.
  • To discuss the integration of experimental and computational approaches.

Main Methods:

  • Single-cell analysis in vivo
  • Advanced genetic tools
  • Animal models
  • Advanced imaging techniques
  • In silico modeling and dynamic imaging

Main Results:

  • New insights into endothelial cell form, function, and behavior during angiogenesis.
  • Improved understanding of cooperative cellular behaviors driving vascular network patterning.
  • Detailed examination of molecular mechanisms regulating key angiogenic processes.

Conclusions:

  • Vascular development is a complex process understood through cellular resolution.
  • Endothelial cell biology is central to angiogenesis.
  • Integrated experimental and computational methods enhance our understanding of vascular networks.