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Updated: May 27, 2026

3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol
Published on: May 12, 2019
The big and the small: challenges of imaging the brain's circuits
Jeff W Lichtman1, Winfried Denk
1Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA. jeff@mcb.harvard.edu
Abstract:
The relation between the structure of the nervous system and its function is more poorly understood than the relation between structure and function in any other organ system. We explore why bridging the structure-function divide is uniquely difficult in the brain. These difficulties also explain the thrust behind the enormous amount of innovation centered on microscopy in neuroscience. We highlight some recent progress and the challenges that remain.

