Related Experiment Video
Updated: May 27, 2026
08:13
Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice
Published on: September 30, 2021
Patients with isolated prolonged in vitro bleeding time. Clinical symptoms
1Goethe University Hospital, Frankfurt Haemophilia Centre, Medical Clinic III / Inst. of Transfusion medicine, Frankfurt, Germany. rosa.alesci@kgu.de
Hamostaseologie
|November 8, 2011
Summary
Patients with prolonged bleeding time often experience various bleeding symptoms, with hematomas being the most common. This study suggests von Willebrand disease may not be the cause.
Area of Science:
- Hematology
- Clinical Diagnostics
Background:
- A standardized treatment approach for patients with isolated prolonged in vitro bleeding time is lacking.
- Characterizing bleeding symptoms in this patient group is crucial for understanding their clinical presentation.
Purpose of the Study:
- To investigate and characterize the spectrum of bleeding symptoms in patients with isolated prolonged bleeding time.
- To explore potential underlying causes, such as von Willebrand disease, in this cohort.
Main Methods:
- Excluded patients with known causes of prolonged bleeding time (e.g., platelet dysfunction, medication effects, von Willebrand disease).
- Utilized the PFA-100 (platelet function analyzer) with epinephrine and ADP cartridges to assess bleeding time.
- Collected comprehensive bleeding symptom data from 75 patients (58 women, 17 men) using a detailed questionnaire.
Main Results:
- Postoperative bleeding occurred in 69.8% of patients who had undergone surgery.
- Hematomas were reported by 71% of patients, gum bleeding by 33.8%, and bleeding after dental procedures by 40.8%.
- Frequent epistaxis was reported by 41.4% of patients; no correlation was found between prolonged bleeding time and VWF:Ag, VWF:RCo, or ROTEM® analysis.
Conclusions:
- Patients with isolated prolonged PFA are predominantly women and exhibit a wide range of bleeding symptoms.
- Hematoma is the most frequent bleeding symptom observed in this cohort.
- The findings suggest that von Willebrand disease may not be the primary cause of isolated prolonged bleeding time in these patients.
Related Concept Videos
01:24Disorders of Hemostasis
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
01:28Esophageal Varices-II: Clinical Features and Management
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...
01:20Inflammatory Bowel Disease IV: Clinical Manifestations
Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
01:25Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
01:23Gastritis III: Clinical Manifestations and Management
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
01:30Venous Thrombosis IV: Nursing Management
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...