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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Published on: July 19, 2019

Multiple sclerosis and depression.

Anthony Feinstein1

  • 1Department of Psychiatry, University of Toronto, Sunnybrook Health Sciences Centre, Canada. antfeinstein@aol.com

Multiple Sclerosis (Houndmills, Basingstoke, England)
|November 8, 2011
PubMed
Summary
This summary is machine-generated.

Depression affects up to 50% of multiple sclerosis patients, impacting quality of life. Early diagnosis and treatment are crucial, yet often overlooked in neurological settings.

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Area of Science:

  • Neurology
  • Psychiatry
  • Neuroimmunology

Background:

  • Depression is a common and serious comorbidity in multiple sclerosis (MS), affecting up to 50% of patients.
  • It significantly increases morbidity and mortality and is a major factor influencing patient quality of life.
  • Depression in MS is often underdiagnosed and undertreated despite available interventions.

Purpose of the Study:

  • To review current knowledge on the diagnosis and management of depression in multiple sclerosis.
  • To highlight the link between depression and structural brain changes in MS, including those seen in diffusion tensor imaging.
  • To discuss biological and psychosocial factors contributing to mood changes in MS patients.

Main Methods:

  • Literature review of current perspectives on depression in multiple sclerosis.
  • Analysis of data from randomized controlled trials on treatment efficacy.
  • Examination of studies investigating the association between depression and neuroimaging findings.

Main Results:

  • Self-report screening questionnaires can aid in diagnosis.
  • Suicidal intent requires careful monitoring.
  • Structural brain abnormalities, visualized through techniques like diffusion tensor imaging, are associated with depression in MS.
  • Antidepressant medication, cognitive behavior therapy, and mindfulness therapy show efficacy in treating depression.

Conclusions:

  • Depression is a significant and treatable condition in multiple sclerosis.
  • Integrated care approaches are needed to improve diagnosis and treatment rates.
  • Further research into the neurobiological underpinnings of depression in MS is warranted.