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Updated: May 27, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Ethyl 4-[3-(1H-imidazol-1-yl)propyl-amino]-3-nitro-benzoate
Abstract:
In the title compound, C(15)H(18)N(4)O(4), the 1H-imidazole ring forms a dihedral angle of 67.12 (8)° with the benzene ring. An S(6) ring motif is formed via an intra-molecular N-H⋯O hydrogen bond. In the crystal, neighbouring mol-ecules are linked by a pair of inter-molecular N-H⋯N hydrogen bonds, forming an inversion dimer. The dimers are further linked by a pair of C-H⋯O hydrogen bonds, leading to the formation of chain along [021]. A C-H⋯π inter-action involving the centroid of the benzene ring is also observed between the chains.
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