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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

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A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease
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A database for chemical proteomics: ChEBI.

Paula de Matos1, Nico Adams, Janna Hastings

  • 1European Bioinformatics Institute, Hinxton, UK. pmatos@ebi.ac.uk

Methods in Molecular Biology (Clifton, N.J.)
|November 9, 2011
PubMed
Summary
This summary is machine-generated.

The Chemical Entities of Biological Interest (ChEBI) database offers a vital, free resource for chemical proteomics. It catalogs small molecules and their biological roles, aiding protein target identification.

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Area of Science:

  • Biochemistry
  • Bioinformatics
  • Chemical Biology

Background:

  • Chemical proteomics requires comprehensive small molecule data for identifying protein targets.
  • Existing resources may lack the scope or accessibility needed for advanced research.
  • A centralized, high-quality database is crucial for the field's progression.

Purpose of the Study:

  • To highlight the Chemical Entities of Biological Interest (ChEBI) database as an essential resource for chemical proteomics.
  • To describe the scope and features of the ChEBI database.
  • To emphasize its utility in discovering small molecule-protein interactions and biological roles.

Main Methods:

  • The ChEBI database curates a wide range of chemical entities, including natural and synthetic products.
  • It incorporates a chemical ontology to establish relationships between molecules.
  • Data integration provides access to related bioinformatics resources like pathways and protein structures.

Main Results:

  • ChEBI provides a broad and detailed catalog of chemical entities relevant to biological processes.
  • The integrated chemical ontology facilitates data discovery and understanding of molecular relationships.
  • ChEBI serves as a central hub for accessing diverse biological and chemical data.

Conclusions:

  • The Chemical Entities of Biological Interest (ChEBI) database is indispensable for chemical proteomics research.
  • Its comprehensive data and ontological structure enhance the identification of small molecule targets.
  • ChEBI supports interdisciplinary research by linking chemical information with biological context.