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Updated: May 27, 2026
12:17
Detection and Isolation of Apoptotic Bodies to High Purity
Published on: August 12, 2018
ApoptoProteomics, an integrated database for analysis of proteomics data obtained from apoptotic cells
Magnus Ø Arntzen1, Bernd Thiede
1Biotechnology Centre of Oslo, University of Oslo, 0317 Oslo, Norway.
Molecular & Cellular Proteomics : MCP
|November 10, 2011
Summary
The ApoptoProteomics database integrates proteomic data from apoptosis studies, aiding research into programmed cell death and related human diseases. It helps analyze complex datasets and identify key proteins involved in apoptosis signaling pathways.
Area of Science:
- Cell Biology
- Biochemistry
- Bioinformatics
Background:
- Apoptosis, a crucial programmed cell death, is linked to numerous human diseases.
- Quantitative proteomic analyses of apoptosis generate vast, complex datasets.
- Evaluating these datasets is challenging for researchers.
Purpose of the Study:
- To develop a centralized database for apoptosis proteomics data.
- To facilitate storage, browsing, and analysis of large-scale proteomic studies on apoptosis.
- To integrate diverse data sources for comprehensive analysis.
Main Methods:
- Integrated proteomics data from 52 publications on apoptosis in human, mouse, and rat.
- Unified data with annotations from UniProt-KB, CASBAH, and Gene Ontology.
- Developed the ApoptoProteomics database for data management and analysis.
Main Results:
- The database contains over 2300 records for more than 1500 unique proteins involved in apoptosis.
- Analysis shows agreement between proteomic data and known apoptosis functions.
- Identified potential novel proteins involved in apoptosis and hundreds of caspase substrates.
Conclusions:
- The ApoptoProteomics database provides a valuable resource for apoptosis research.
- It aids in understanding apoptosis signaling pathways and identifying disease-related proteins.
- Proteomics significantly contributes to discovering caspase substrates and apoptosis mechanisms.
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