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Related Concept Videos

Phase II Reactions: Acetylation Reactions01:24

Phase II Reactions: Acetylation Reactions

Acetylation, a phase II biotransformation reaction, introduces an acetyl group to drugs or their metabolites. Acetyltransferase enzymes facilitate this reaction, which resembles α-amino acid conjugation due to the addition of a functional group to the drug molecule.
The substrates for acetylation are typically drugs or their metabolites with an amino, sulfonamide, or hydrazine functional group. Acetylation can occur at several points in the drug molecule, including primary, secondary, and...
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer is an enzyme that can...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

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Updated: May 27, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates
14:32

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates

Published on: February 27, 2016

Protein acetylation and aging.

Jin-Ying Lu, Yu-Yi Lin, Heng Zhu

    Aging
    |November 10, 2011
    PubMed
    Summary
    This summary is machine-generated.

    This study reveals that targeting an internal aging process, separate from diet, may offer new therapeutic strategies. This approach could overcome limitations associated with traditional calorie restriction methods.

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    A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli
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    Published on: December 9, 2017

    Related Experiment Videos

    Last Updated: May 27, 2026

    Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates
    14:32

    Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates

    Published on: February 27, 2016

    Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications
    09:29

    Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

    Published on: May 18, 2017

    A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli
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    A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli

    Published on: December 9, 2017

    Area of Science:

    • Gerontology and molecular biology
    • Cellular aging mechanisms

    Background:

    • Calorie restriction (CR) is a known intervention to extend lifespan but has practical limitations.
    • Understanding intrinsic aging pathways independent of nutrient sensing is crucial for developing alternative anti-aging strategies.

    Purpose of the Study:

    • To investigate the potential of manipulating intrinsic aging pathways.
    • To explore therapeutic avenues that bypass the challenges of calorie restriction.

    Main Methods:

    • The study focused on intrinsic aging pathways.
    • Experimental models were used to assess the effects of manipulating these pathways.

    Main Results:

    • Results indicate that intrinsic aging pathways can be targeted independently of nutrition.
    • This manipulation shows potential as a therapeutic strategy.

    Conclusions:

    • Targeting intrinsic aging pathways offers a promising therapeutic approach.
    • This method may circumvent the limitations associated with calorie restriction, providing a novel route for aging interventions.