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Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
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Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
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Inflammatory Bowel Disease IV: Clinical Manifestations

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Updated: May 27, 2026

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

Transient myocarditis associated with fulminant colitis.

J M L Williamson1, R S J Dalton

  • 1Department of Surgery, Musgrove Park Hospital, Tauntonl, Somerset, TA1 5DA, UK.

ISRN Surgery
|November 16, 2011
PubMed
Summary

Fulminant colitis can rapidly lead to severe cardiac issues. Giant cell myocarditis (GCM) is a rare but serious potential cause of left ventricular failure in young patients with inflammatory bowel disease.

Area of Science:

  • Cardiology
  • Gastroenterology
  • Pathology

Background:

  • Inflammatory bowel disease (IBD) encompasses chronic gastrointestinal inflammation.
  • Fulminant colitis, a severe form of IBD, presents with rapid deterioration.
  • Cardiac complications are uncommon but significant in severe colitis.

Observation:

  • An 18-year-old male presented with severe abdominal pain, weight loss, and bloody diarrhea.
  • Diagnostic imaging confirmed colitis with rectal sparing; conservative management failed.
  • Following subtotal colectomy, the patient developed acute left ventricular failure.

Findings:

  • The patient's cardiac failure resolved spontaneously, raising suspicion for transient myocarditis.
  • Giant cell myocarditis (GCM) was considered as a potential cause, a rare association with IBD.

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Quantitative Visualization of Leukocyte Infiltrate in a Murine Model of Fulminant Myocarditis by Light Sheet Microscopy

Published on: May 31, 2017

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Last Updated: May 27, 2026

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
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Published on: December 8, 2014

Quantitative Visualization of Leukocyte Infiltrate in a Murine Model of Fulminant Myocarditis by Light Sheet Microscopy
06:49

Quantitative Visualization of Leukocyte Infiltrate in a Murine Model of Fulminant Myocarditis by Light Sheet Microscopy

Published on: May 31, 2017

  • GCM typically affects younger individuals with variable prognoses.

    • Implications:

    • Fulminant colitis can precipitate acute cardiac dysfunction through sepsis, systemic inflammatory response, or myocarditis.
    • Giant cell myocarditis should be considered in young patients with rapid-onset left ventricular failure.
    • This case highlights the critical need for cardiac monitoring in severe colitis presentations.