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Related Concept Videos

RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
RNA Interference01:23

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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
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A Rapid High-throughput Method for Mapping Ribonucleoproteins (RNPs) on Human pre-mRNA
13:00

A Rapid High-throughput Method for Mapping Ribonucleoproteins (RNPs) on Human pre-mRNA

Published on: December 2, 2009

Plug and play with RNA.

Günter Mayer1, Sabine Lennarz, Falk Rohrbach

  • 1Life & Medical Sciences Institute, University of Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany. gmayer@uni-bonn.de

Angewandte Chemie (International Ed. in English)
|November 17, 2011
PubMed
Summary
This summary is machine-generated.

RNA aptamers, high-affinity ligands, enable the creation of complex molecules. Recent studies showcase their use in tracking endogenous RNA dynamics and assembling multi-enzyme complexes for controlled chemical production.

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Area of Science:

  • Molecular Biology
  • Biochemistry
  • Synthetic Biology

Background:

  • RNA aptamers are versatile molecules with high-affinity binding capabilities.
  • Their potential for assembling complex structures and functional complexes is increasingly recognized.

Purpose of the Study:

  • To explore novel applications of RNA aptamers in biological research and biotechnology.
  • To demonstrate the utility of RNA aptamers in studying RNA dynamics and in synthetic biology.

Main Methods:

  • Development of a GFP-like RNA reporter for endogenous RNA dynamics.
  • Design of an aptamer-templated system for assembling multi-enzyme complexes in bacteria.

Main Results:

  • Successful implementation of an RNA reporter to monitor endogenous RNA dynamics.
  • Demonstration of controlled production of secondary molecules via aptamer-templated enzyme assembly.

Conclusions:

  • RNA aptamers offer powerful tools for both fundamental biological research and biotechnological applications.
  • These studies highlight the adaptability of RNA aptamers in creating functional molecular systems.