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Updated: May 27, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
2-(4-Iodo-phen-yl)-1,2,3,4-tetra-hydro-isoquinoline-1-carbonitrile
Abstract:
In the title compound, C(16)H(13)IN(2), the benzene ring of the tetra-hydro-isoquinoline moiety makes a dihedral angle of 45.02 (9)° with the benzene ring of the 4-iodo-phenyl fragment. The N atom and the adjacent unsubstituted C atom of the tetra-hydro-isoquinoline unit are displaced by 0.294 (2) and 0.441 (3) Å, respectively, from the plane through the remaining eight C atoms. In the crystal, pairs of adjacent mol-ecules are linked into dimers by weak inter-molecular C-H⋯π inter-actions.
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