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Updated: May 27, 2026

Guidelines and Experience Using Imaging Biomarker Explorer (IBEX) for Radiomics
Published on: January 8, 2018
A framework for assessing the value of diagnostic imaging in the era of comparative effectiveness research
G Scott Gazelle1, Larry Kessler, David W Lee
1Department of Radiology, Institute for Technology Assessment, Massachusetts General Hospital, 101 Merrimac St, 10th Floor, Boston, MA 02114-4724, USA. scott@mgh-ita.org
Abstract:
In June 2009, the Federal Coordinating Council for Comparative Effectiveness Research submitted a report to the President and Congress in which the Council described the purpose of comparative effectiveness research (CER) as developing evidence-based information for interventions and determining under what circumstances an intervention is effective (1). With the enactment of the Patient Protection and Affordable Care Act, a Patient-centered Outcomes Research Institute (PCORI) was established to assist decision makers in making evidence-based health decisions through synthesis and dissemination of clinical CER of health interventions (2). Its founding has underscored a heightened need for health policy makers to consider the impact of health care technologies on final outcomes of interest--for example, functional status, quality of life, disability, major clinical events, and mortality (3-5).
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