Related Experiment Video
Updated: May 27, 2026
09:18
Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
Published on: January 12, 2019
Physical functioning in boys with hemophilia in the U.S
Paul E Monahan1, Judith R Baker, Brenda Riske
1Department of Pediatrics, Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7016, USA. Paul_Monahan@med.unc.edu
American Journal of Preventive Medicine
|November 22, 2011
Summary
Children with hemophilia (an inherited bleeding disorder) face physical limitations due to recurrent hemorrhages. Key risk factors include age, joint bleeds, inhibitors, obesity, and Medicaid insurance, highlighting needs for targeted interventions and equitable care.
Area of Science:
- Pediatric Hematology
- Orthopedics
- Public Health
Background:
- Hemophilia is a common inherited severe bleeding disorder.
- Recurrent hemorrhages lead to joint disease and variable functional impairment.
Purpose of the Study:
- To identify characteristics associated with physical functioning limitations in boys with hemophilia.
- To analyze a national database for risk factors of functional decline due to bleeding.
Main Methods:
- Utilized data from the Universal Data Collection (UDC) program (1998-2008).
- Examined 15 potential predictors in boys aged ≤18 years.
- Performed bivariate and multivariate analyses on activity limitations, absenteeism, and mobility aid reliance.
Main Results:
- Increasing age, joint bleeding, and inhibitor antibodies independently predicted poor physical function.
- African-American race and Asian/Pacific Island ethnicity were associated with activity restrictions and absenteeism, respectively.
- Obesity and Medicaid insurance were linked to multiple poor functional outcomes.
Conclusions:
- Interventions should target inhibitor elimination, support for African-American children, and weight management.
- Ensuring adequate insurance coverage is crucial to overcome economic barriers to optimal outcomes.
Related Concept Videos
01:24Disorders of Hemostasis
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
01:43Sex-linked Disorders
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
01:20Overview of Hematopoiesis
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
01:27Signs of Puberty
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
01:20Disorders of the Male Reproductive System
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
01:27Assessment of the Cardiovascular System III: Palpation
Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above the...
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above the...