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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...

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Related Experiment Video

Updated: May 27, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
07:40

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

Chronic anterior uveitis in common variable immunodeficiency.

Erica Z Oltra, Cody Morris, Andrea D Birnbaum

    Ocular Immunology and Inflammation
    |November 24, 2011
    PubMed
    Summary
    This summary is machine-generated.

    Common variable immunodeficiency (CVID) can cause chronic anterior uveitis. Patients with uveitis should be evaluated for CVID, especially if they have frequent infections or autoimmune conditions.

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    Area of Science:

    • Ophthalmology
    • Immunology
    • Rheumatology

    Background:

    • Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by impaired antibody production.
    • Uveitis, inflammation of the middle layer of the eye, can have diverse etiologies, including autoimmune and infectious causes.

    Observation:

    • This study describes three patients diagnosed with both CVID and uveitis.
    • All identified patients presented with chronic anterior uveitis.

    Findings:

    • Two out of three patients required systemic immunosuppression for uveitis management.
    • One patient experienced a relapse of uveitis after discontinuing immunoglobulin therapy, highlighting the chronic nature of the condition.
    • Topical steroid therapy provided improvement in one patient, though long-term outcomes were not assessed.

    Implications:

    • CVID should be considered in the differential diagnosis of patients presenting with chronic anterior uveitis.
    • A thorough patient history, including inquiries about recurrent infections and autoimmune disorders, is crucial for diagnosing CVID in uveitis patients.