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Updated: May 27, 2026

Advanced Confocal Microscopy Techniques to Study Protein-protein Interactions and Kinetics at DNA Lesions
Published on: November 12, 2017
Mechanism of UV-induced formation of Dewar lesions in DNA
Karin Haiser1, Benjamin P Fingerhut, Korbinian Heil
1Faculty of Physics, Center for Integrative Protein Science, Ludwig Maximilians University Munich, Oettingenstrasse 67, 80538 Munich, Germany.
Abstract:
The importance of a backbone: The mechanism of formation of Dewar lesions has been investigated by using femtosecond IR spectroscopy and ab initio calculations of the exited state. The 4π electrocyclization is rather slow, occurs with an unusual high quantum yield, and--surprisingly--is controlled by the phosphate backbone.
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