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Related Concept Videos

Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
Membrane Domains01:18

Membrane Domains

The membrane domains concentrate specific lipids and proteins at one place within the membrane, which helps in cell signaling, adhesion, and other critical cellular processes. These domains can differ in size, composition, function, and lifespan.
Protein Domains
The membrane comprises a group of distinct proteins responsible for carrying out a cell's specific function. For example, the plasma membrane of the human sperm, or a single germ cell, contains a unique set of proteins in the anterior...
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Mechanisms of Membrane Domain Formation00:59

Mechanisms of Membrane Domain Formation

Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
Another mechanism for membrane domain formation involves membrane proteins interacting with cytoskeletal...
Structural Protein Function01:56

Structural Protein Function

Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to form...
Structural Protein Function01:56

Structural Protein Function

Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to form...

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Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

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Published on: May 8, 2015

STAS domain structure and function.

Alok K Sharma1, Alan C Rigby, Seth L Alper

  • 1Molecular and Vascular Medicine Division, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA 02215, USA. aksharma@bidmc.harvard.edu

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
|November 26, 2011
PubMed
Summary
This summary is machine-generated.

The Sulfate Transporter and Anti-Sigma factor antagonist (STAS) domain is crucial for anion transporter function and cellular processes. This review details STAS domain structure, diverse functions, and disease associations.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Structural Biology

Background:

  • Pendrin and other SLC26/SulP transporters possess a carboxy-terminal cytoplasmic STAS domain.
  • STAS domains exhibit a conserved structural fold despite divergent amino acid sequences.

Purpose of the Study:

  • To review the structure and diverse functions of the STAS domain.
  • To highlight the role of STAS domains in anion transport and cellular signaling.

Main Methods:

  • Literature review of STAS domain structure and function.
  • Analysis of STAS domain conservation and evolutionary relationships.

Main Results:

  • STAS domains are found in various proteins, including anti-sigma factors, sensors, and metabolic enzymes.
  • STAS domains mediate interactions with other proteins, forming functional complexes like metabolons.
  • STAS domains are essential for membrane targeting of transporters and mutations are linked to human diseases.

Conclusions:

  • The STAS domain is a versatile module involved in transport, signaling, and metabolism.
  • Understanding STAS domain structure-function relationships is key to deciphering its biological roles and associated pathologies.