Related Experiment Video
Updated: May 27, 2026

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury
Published on: February 10, 2020
Natural course of epilepsy concomitant with CNS tuberculomas
Abdulaziz AlSemari1, Salah Baz, Fahad Alrabiah
1Neurology Section, Department of Neurosciences, King Faisal Specialist Hospital & Research Centre, MBC 76, P.O. Box 3354, Riyadh 11211, Saudi Arabia. alsemari@kfshrc.edu.sa
Background:
Epilepsy is relatively common in CNS tuberculomas, but its natural course is unclear.
Aim:
To determine the prevalence and prognosis of epilepsy in patients with seizures related to CNS tuberculomas.
Methods:
We retrospectively reviewed the charts of patients with CNS tuberculomas who presented at our institution between 1983 and 2001.
Results:
Seizures occurred in 22 of 93 (23.6%) of the patients with CNS tuberculomas. These patients were treated with standard antituberculous therapy for a period varying between 6 and 20 months. Sixty-three out of 93 patients were cured of tuberculosis, and 21 of the 63 (33%) who had concomitant epilepsy became seizure-free. TB recurred in 3 patients, and 1 out of 22 who had concomitant epilepsy continued to have seizures; 3 died and 24 were lost to follow-up. Anti-epileptic medications were discontinued after completion of the anti-TB course.
Conclusion:
Seizures are commonly associated with CNS tuberculomas and most often resolve after successful treatment of the underlying CNS tuberculosis.
Related Concept Videos
Brain Abscess l: Introduction
Epilepsy ll: Types
Encephalitis l: Introduction
Seizures l: Introduction
Epilepsy and Seizures: Overview
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Encephalitis ll: Pathophysiology

