Myocardial deformation analysis in Chagas heart disease with the use of speckle tracking echocardiography

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Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
09:05

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

Published on: October 20, 2016

Ana García-Álvarez1, Marta Sitges, Ander Regueiro

  • 1Cardiology Department, Thorax Clinic Institute, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

Journal of Cardiac Failure
|November 30, 2011
PubMed

Insights

Myocardial deformation assessment using speckle tracking echocardiography reveals reduced radial strain in Chagas disease patients. This technique aids in early detection of cardiac involvement in the indeterminate form.

Area of Science:

  • Cardiology
  • Echocardiography
  • Medical Diagnostics

Background:

  • Chagas disease can lead to myocardial involvement, impacting heart function.
  • Early detection of cardiac involvement is crucial for managing Chagas disease.
  • Understanding myocardial deformation aids in elucidating disease pathophysiology.

Purpose of the Study:

  • To characterize myocardial deformation in various forms of Chagas disease.
  • To specifically compare myocardial deformation between patients in the indeterminate form and healthy controls.
  • To identify sensitive markers for early cardiac involvement in Chagas disease.

Main Methods:

  • Speckle tracking echocardiography was utilized to assess myocardial deformation.
  • 98 subjects were included: 22 with Chagas cardiomyopathy, 32 in the indeterminate form, and 44 controls.
  • Quantified global and segmental left ventricular (LV) radial, circumferential, and longitudinal strain; also assessed LV twist and untwisting velocities in a subset.

Main Results:

  • A significant decreasing trend in global radial, circumferential, and longitudinal strain was observed across the groups.
  • Patients in the indeterminate form showed significantly lower global radial strain and mid-inferior segment radial strain compared to controls.
  • Reduced LV peak systolic twist and untwisting velocities were also noted in the indeterminate form compared to controls.

Conclusions:

  • Myocardial deformation analysis, especially radial strain, is a sensitive method for detecting cardiac involvement in Chagas disease patients.
  • This technique offers valuable insights into the pathophysiology of Chagas heart disease.
  • Radial strain evaluation can aid in the early identification of myocardial involvement in the indeterminate form of Chagas disease.
Abstract

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