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Related Concept Videos

Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
Vaccinations01:51

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Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cross-reactivity00:42

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Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Vaccine Production01:23

Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...

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Related Experiment Video

Updated: May 27, 2026

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
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Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

Varicella vaccines.

Saba Javed1, Syed A Javed, Stephen K Tyring

  • 1University of Texas Medical School at Houston, University of Texas Health, Houston, Texas, USA. saba.javed@uth.tmc.edu

Current Opinion in Infectious Diseases
|November 30, 2011
PubMed
Summary
This summary is machine-generated.

Varicella vaccine is safe and effective in immunocompromised children, stimulating a good immune response. Further research is needed for herpes zoster vaccine in immunodeficient adults to reduce viral infections.

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Expression and Purification of Virus-like Particles for Vaccination

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Area of Science:

  • Immunology
  • Vaccinology
  • Virology

Background:

  • Live attenuated vaccines for varicella and herpes zoster are available.
  • Varicella vaccine is typically given to immunocompetent individuals, despite evidence of safety in immunocompromised groups.
  • Herpes zoster vaccine is effective in healthy adults but has low uptake.

Purpose of the Study:

  • To review the safety and immunogenicity of varicella vaccine in immunocompromised populations.
  • To discuss the potential benefits of varicella and herpes zoster vaccines in specific patient groups.
  • To highlight the need for further research on herpes zoster vaccine in immunodeficient adults.

Main Methods:

  • Review of recent studies on varicella vaccine in children with various immunocompromising conditions.
  • Analysis of existing literature on varicella and herpes zoster vaccine safety and efficacy.
  • Examination of immune responses in specific patient cohorts.

Main Results:

  • Varicella vaccine demonstrated immunogenicity in children with hematological malignancies, inflammatory bowel disease, HIV, atopic dermatitis, and juvenile rheumatic diseases.
  • The vaccine is generally well-tolerated in these moderately immunocompromised pediatric populations.
  • Herpes zoster vaccine is well-tolerated and effective in healthy adults, but vaccination rates are low.

Conclusions:

  • Varicella vaccine appears safe and immunogenic in moderately immunocompromised children, potentially reducing viral infection burden.
  • Further studies are warranted to evaluate the herpes zoster vaccine in immunodeficient adults.
  • Herpes zoster vaccination may decrease the incidence of herpes zoster and postherpetic neuralgia.