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Quercetin alleviates bisphenol A-induced changes in nucleic acid and protein contents in mice
Neha P Sangai1, J Ramtej Verma
1Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad-380 009, Gujarat, India.
Abstract:
The present study was an attempt to examine toxic effects of bisphenol A in liver and kidney of mice and its alleviation by quercetin. Oral administration of bisphenol A (60 and 120 mg/kg b. w./day) for 30 days caused, as compared to vehicle control significant, dose-dependent decrease in DNA, RNA and protein contents in liver and kidney of mice. Supplementation of quercetin (60 mg/kg b. w./day) along with bisphenol A for 30 days caused, as compared to bisphenol A alone treated groups, significant alleviation in DNA, RNA and protein contents. The amelioration was comparatively higher for high dose bisphenol A plus quercetin treated group than that of low dose plus quercetin treated group.
