Related Experiment Video
Updated: May 27, 2026
06:51
A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
Verruciform xanthoma in an adolescent: a case report
Molly Ann Frankel1, Helen E Rhodes, Elizabeth D Euscher
1Department of Nursing, Professional Education for Prevention and Early Detection, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. mfrankel@mdanderson.org
Journal of Lower Genital Tract Disease
|December 1, 2011
Summary
Verruciform xanthoma is a rare, benign skin lesion. Wide local excision is the only effective treatment for this condition, which can mimic other vulvar growths.
Area of Science:
- Dermatology
- Pathology
Background:
- Verruciform xanthoma presents as a benign mucocutaneous lesion with characteristic epidermal hyperplasia and hyperkeratosis.
- It is considered a reactive process, not neoplastic, often linked to epithelial damage and foamy histiocytes.
- Human papillomavirus is not a confirmed causative agent, and differential diagnoses include verrucous carcinoma and condyloma acuminatum.
Observation:
- This report details a case of verruciform xanthoma affecting the vulva in a 16-year-old female.
- This represents the third documented instance of verruciform xanthoma in an adolescent girl.
Findings:
- Verruciform xanthoma exhibits a verrucous, papillary morphology with prominent foam cells.
- Histopathological examination reveals lipid-laden macrophages within the epidermal layers.
Implications:
- Accurate diagnosis is crucial as verruciform xanthoma can be mistaken for other vulvar conditions.
- Standard treatments for wartlike lesions are ineffective; wide local excision is the recommended curative approach.
- This case highlights the importance of surgical management for verruciform xanthoma in adolescents.
Related Concept Videos
01:27Acne Infection
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
01:30Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
02:23Abnormal Proliferation
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...