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Updated: May 27, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
Progressive craniofacial bone loss after cosmetic surgery at the forehead
Annie P Prasad1, Vijay George, Anne Porzig
1Department of Radiology and Biomedical Imaging, University of California San Francisco, 400 Parnassus Ave., A 367, Box 0628, San Francisco, CA 94143-0628, USA.
A 59-year-old woman experienced progressive skull indentations after forehead plastic surgery. Imaging and biopsy revealed bone resorption due to synthetic material, posing a risk of cerebral injury.
Area of Science:
- Plastic Surgery
- Neurosurgery
- Radiology
Background:
- Cosmetic facial surgery, particularly forehead augmentation, carries potential risks.
- Monitoring post-operative complications is crucial for patient safety.
Observation:
- A 59-year-old woman presented with progressive frontal skull indentations 3 years after forehead plastic surgery.
- Computed Tomography (CT) and Magnetic Resonance (MR) scans showed significant frontal bone thinning and lytic skull lesions.
- Histological examination of biopsies from the lesions revealed fibrotic tissue and synthetic residue from the cosmetic procedure, with no signs of infection or malignancy.
Findings:
- The patient exhibited progressive cranial bone resorption, leading to skull deformation.
- The bone loss was attributed to a foreign body reaction to synthetic materials used in the prior cosmetic surgery.
Implications:
- Progressive cranial bone resorption presents a significant risk for cerebral injury.
- This case underscores the importance of considering long-term complications, including bone resorption, following cosmetic facial surgery.
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