Spectroscopic imaging with prospective motion correction and retrospective phase correction.

Area of Science:

• Neuroimaging
• Medical Physics
• Spectroscopy

Background:

• Motion artifacts in magnetic resonance spectroscopic imaging (MRSI) are challenging to detect and can lead to misinterpretation.
• Prospective motion correction (PMC) using optical tracking has shown success in single-voxel spectroscopy.
• The effectiveness of PMC in conjunction with retrospective correction for MRSI in the brain requires further evaluation.

Purpose of the Study:

• To evaluate the utility of prospective motion correction combined with retrospective phase correction for human brain MRSI.
• To assess the impact of this combined correction methodology on motion-induced data degradation.

Main Methods:

• Implementation of prospective motion correction using an optical tracking system.
• Application of retrospective phase correction utilizing the interleaved reference scan method.
• Evaluation of the combined correction technique on spectroscopic imaging data from the human brain.

Main Results:

• The combined prospective and retrospective correction methodology was applied to human brain MRSI data.
• The technique demonstrated a reduction in motion-induced artifacts and data degradation.
• Correct phasing of spectra across the entire spectroscopic imaging slice was achieved.

Conclusions:

• Prospective motion correction, when combined with retrospective phase correction, is effective for human brain MRSI.
• This integrated approach mitigates motion-induced artifacts, enhancing the reliability of MRSI data.
• The findings support the use of this methodology for improved accuracy in brain spectroscopy.