Related Experiment Video
Updated: May 27, 2026

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
Progressive constriction of the hyperautofluorescent ring in retinitis pigmentosa
Luiz H Lima1, Tomas Burke, Vivienne C Greenstein
1Vitreous, Retina, Macula Consultants of New York, New York, New York 10032, USA.
Purpose:
To evaluate the constriction of the hyperautofluorescent ring over time in patients with retinitis pigmentosa (RP).
Design:
Prospective study.
Methods:
Fourteen eyes of 14 RP patients with a hyperautofluorescent ring were studied. Ring constriction was evaluated by measurements of its external and internal boundaries along the vertical and horizontal axes at baseline and at 12-, 24-, 36-, and 48-month follow-ups. Repeat fundus autofluorescence was obtained at 12, 24, 36, and 48 months in 13, 7, 5, and 1 eyes respectively. Spectral-domain optical coherence tomography (SD-OCT) images were obtained on 8 eyes and the horizontal extent of the inner segment/outer segment (IS/OS) junction was measured. SD-OCT was repeated at 12 and 24 months in 6 and 4 eyes respectively.
Results:
The external boundaries of the ring were identified along the horizontal axis in 12 eyes and along the vertical axis in 13. Internal boundaries were identified in 7 eyes. Constriction was demonstrated in all patients except 1 who demonstrated minimal expansion of the internal boundary along the horizontal axis. SD-OCT measurements showed a decrease in the IS/OS junction length.
Conclusion:
Progressive constriction of the hyperautofluorescent ring and a concordant decrease in IS/OS junction length were observed over time.
Related Concept Videos
Diabetic Retinopathy
Photoreceptors and Visual Pathways
Anatomy of the Eyeball
