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Spontaneously occurring congenital polycystic kidney in a cynomolgus monkey (Macaca fascicularis)

I Sakakibara1, S Honjo

  • 1Tsukuba Primate Center for Medical Science, National Institute of Health, Ibaragi-Ken, Japan.

Journal of Medical Primatology
|January 1, 1990
PubMed

Insights

A stillborn cynomolgus monkey exhibited congenital polycystic kidney disease, mirroring human infantile forms. However, unlike human and rhesus cases, this monkey lacked intrahepatic bile duct expansion.

Area of Science:

  • Veterinary Pathology
  • Primate Medicine
  • Developmental Biology

Background:

  • Congenital polycystic kidney disease (CPKD) is a severe genetic disorder affecting kidney development.
  • Infantile polycystic kidney disease (IPKD) presents a specific phenotype in humans and rhesus monkeys.
  • Non-human primates serve as valuable models for studying human diseases due to physiological similarities.

Observation:

  • A stillborn male cynomolgus monkey (Macaca fascicularis) was examined post-mortem.
  • The necropsy revealed significant pathological changes consistent with congenital polycystic kidney disease.
  • The observed condition closely resembled infantile polycystic kidney disease found in humans and rhesus monkeys.

Findings:

  • The cynomolgus monkey presented with congenital polycystic kidney disease.
  • A key distinction from human and rhesus IPKD was the absence of increased intrahepatic bile ducts.
  • This finding highlights potential variations in CPKD presentation across primate species.

Implications:

  • This case expands the understanding of congenital polycystic kidney disease's spectrum in non-human primates.
  • It suggests species-specific differences in the manifestation of polycystic kidney disease.
  • Further research may elucidate the genetic and developmental factors underlying these variations, aiding comparative pathology studies.

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