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Updated: May 27, 2026

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
Published on: December 3, 2016
Skeletal growth patterns in hereditary multiple exostoses: a natural history
Nicholas David Clement1, Andrew D Duckworth, Alexander D L Baker
1Department of Orthopaedics and Trauma, The Royal Infirmary of Edinburgh, Little France, Edinburgh, UK.
Abstract:
Hereditary multiple exostoses (HME) is a commonly inherited musculoskeletal condition and is associated with a diminished stature. We demonstrated that adults with HME were significantly shorter when compared with a control group (P<0.001); preadolescents, however, were significantly taller than predicted (P=0.01). This was reflected by their height centile; 58% of the adults were under the 25th centile, whereas 53% of the preadolescence group were above the 75th centile. Stature was more severely affected in patients with an EXT1 mutation (P=0.008). This study illustrates a novel age-related growth pattern associated with HME, which is also affected by genotype.
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