Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Folding01:22

Protein Folding

Overview
Protein Folding01:25

Protein Folding

Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
Theorems of Pappus and Guldinus: Problem Solving01:12

Theorems of Pappus and Guldinus: Problem Solving

Pappus and Guldinus's theorems are powerful mathematical principles that are used for finding the surface area and volume of composite shapes. For example, consider a cylindrical storage tank with a conical top. Finding the surface area or volume can be challenging for such complex shapes. These theorems are particularly useful in calculating the volume and surface area of such systems. Here, the cylindrical storage tank with a conical top can be broken down into two simple shapes: a cylinder...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

2-Amino-3,4-Dihydroquinazolines Exhibit Potent Antimalarial Activity by Targeting Plasmepsin X.

ACS infectious diseases·2026
Same author

Toward autonomous robotic-assisted and microrobotic surgery.

Science advances·2026
Same author

Molecular integration of seasonal temperature signals in flowering time control.

Nature reviews. Genetics·2026
Same author

A 3D-Printed Scaffolded Hydrogel Microneedle Array Biosensor for Real-Time, Continuous Monitoring.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Ex vivo effects of low dose delayed release rapamycin on agonist-induced platelet aggregation, activation and procoagulant platelet phenotypes in domestic cats.

Scientific reports·2026
Same author

Assessment of Platelet Storage Lesions, Viability, and Function in Canine Platelet Concentrate Units Stored at 4°C for 14 Days.

Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2026

Related Experiment Video

Updated: May 27, 2026

Fabrication of Three-Dimensional Graphene-Based Polyhedrons via Origami-Like Self-Folding
14:52

Fabrication of Three-Dimensional Graphene-Based Polyhedrons via Origami-Like Self-Folding

Published on: September 23, 2018

Algorithmic design of self-folding polyhedra.

Shivendra Pandey1, Margaret Ewing, Andrew Kunas

  • 1Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA.

Proceedings of the National Academy of Sciences of the United States of America
|December 6, 2011
PubMed
Summary

This study reveals geometric principles for designing self-assembling 3D structures. Compactness maximizes yield, and shortest paths guide folding pathways in self-assembly.

More Related Videos

Origami Inspired Self-assembly of Patterned and Reconfigurable Particles
12:33

Origami Inspired Self-assembly of Patterned and Reconfigurable Particles

Published on: February 4, 2013

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Related Experiment Videos

Last Updated: May 27, 2026

Fabrication of Three-Dimensional Graphene-Based Polyhedrons via Origami-Like Self-Folding
14:52

Fabrication of Three-Dimensional Graphene-Based Polyhedrons via Origami-Like Self-Folding

Published on: September 23, 2018

Origami Inspired Self-assembly of Patterned and Reconfigurable Particles
12:33

Origami Inspired Self-assembly of Patterned and Reconfigurable Particles

Published on: February 4, 2013

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Area of Science:

  • Materials Science
  • Nanotechnology
  • Computational Chemistry

Background:

  • Self-assembly offers a powerful method for fabricating complex 3D structures.
  • Limited understanding exists regarding design principles for yield and defect tolerance in self-assembling systems.

Purpose of the Study:

  • To investigate the geometric principles governing the self-folding of 2D nets into submillimeter-scale 3D polyhedra.
  • To identify design rules for enhancing yield and understanding folding pathways in self-assembly.

Main Methods:

  • Computational screening of a vast number of 2D nets to identify suitable candidates.
  • Experimental validation of computationally predicted nets for self-folding into 3D polyhedra.

Main Results:

  • Compactness of 2D nets was identified as a key principle for maximizing the yield of self-folding polyhedra.
  • Shortest paths in configuration space between 2D nets and 3D polyhedra correlate with observed folding pathways.

Conclusions:

  • Compactness and shortest path principles provide a rational basis for designing self-folding polyhedra.
  • This work establishes a model system for the experimental and theoretical study of self-assembly design principles.