Related Experiment Video

Updated: May 27, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Increased miRNA-146a and miRNA-155 expressions in oral lichen planus

Telma Cristina Arão1, André Luiz Sena Guimarães, Alfredo Maurício Batista de Paula

  • 1Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Archives of Dermatological Research
|December 6, 2011
PubMed

Insights

This study found increased levels of microRNA-146a and microRNA-155 in oral lichen planus (OLP) lesions. These findings suggest these microRNAs may play a role in the immune response of this chronic inflammatory condition.

Area of Science:

  • Immunology
  • Molecular Biology
  • Oral Pathology

Background:

  • Oral lichen planus (OLP) is a T helper 1 lymphocyte (Th1)-mediated chronic inflammatory disease.
  • Interferon-gamma (IFN-γ) is crucial in the local immune response within OLP.
  • MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression and are implicated in inflammatory and autoimmune diseases.

Purpose of the Study:

  • To investigate the expression levels of miRNA-146a and miRNA-155 in OLP lesions.
  • To compare miRNA expression in OLP lesions with normal oral mucosa and blood samples.

Main Methods:

  • Quantitative real-time polymerase chain reaction (qPCR) was employed to analyze miRNA expression.
  • The study analyzed 31 OLP lesions, alongside normal oral mucosa and blood samples.

Main Results:

  • A significant increase in the expression of both miRNA-146a and miRNA-155 was observed in OLP lesions.
  • These miRNAs were found to be upregulated in the affected oral tissues.

Conclusions:

  • The findings suggest that miRNA-146a and miRNA-155 are involved in the immune response mechanisms of OLP.
  • These microRNAs represent potential targets for understanding and managing OLP pathogenesis.

More Related Videos

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization06:01

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization

Published on: June 7, 2016

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...