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Carbon dioxide pneumoperitoneum induces systemic oxidative stress: a clinical study
Turhan Aran1, Mesut A Unsal, Suleyman Guven
1Department of Obstetrics and Gynecology, Karadeniz Technical University, Trabzon, Turkey.
European Journal of Obstetrics, Gynecology, and Reproductive Biology
|December 7, 2011
Summary
Carbon dioxide pneumoperitoneum during laparoscopic surgery increases systemic oxidative stress, as indicated by elevated serum ischemia modified albumin (IMA). IMA proves more sensitive than other markers for early detection of this stress.
Area of Science:
- Gynecology
- Minimally Invasive Surgery
- Biochemistry
Background:
- Laparoscopic surgery utilizes carbon dioxide insufflation, potentially inducing systemic oxidative stress.
- Assessing oxidative stress markers is crucial for understanding the physiological impact of laparoscopic procedures.
Purpose of the Study:
- To evaluate the impact of carbon dioxide pneumoperitoneum on systemic oxidative stress using various serum markers.
- To compare the sensitivity of ischemia modified albumin (IMA), malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) at safe intra-abdominal pressures.
Main Methods:
- A prospective study involving 33 patients undergoing laparoscopic ovarian cystectomy.
- Serum samples were collected preoperatively, 10 minutes post-anesthesia, and 30 minutes post-insufflation.
- Levels of IMA, MDA, TOS, OSI, and TAS were measured and compared.
Main Results:
- Serum ischemia modified albumin (IMA) levels significantly increased 30 minutes after carbon dioxide insufflation (p<0.05).
- No significant changes were observed in serum malondialdehyde (MDA), total oxidant status (TOS), oxidative stress index (OSI), or total antioxidant status (TAS).
Conclusions:
- Laparoscopic surgery induces systemic ischemia, detectable through serum IMA measurements.
- IMA demonstrates higher sensitivity than MDA, TOS, OSI, and TAS for the early detection of systemic oxidative stress during laparoscopic procedures.
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