Related Experiment Video
Updated: May 26, 2026

Multimodal Nonlinear Hyperspectral Chemical Imaging Using Line-Scanning Vibrational Sum-Frequency Generation Microscopy
Published on: December 1, 2023
Terahertz spectroscopy: a powerful new tool for the chemical sciences?
Alexander I McIntosh1, Bin Yang, Stephen M Goldup
1Queen Mary University of London, School of Electrical Engineering & Computer Science, Mile End Road, London, E1 4NS, UK.
Terahertz spectroscopy is emerging for chemistry and biology applications. This technique offers unique insights into molecular interactions and crystalline structures, expanding analytical capabilities.
Area of Science:
- Chemistry
- Materials Science
- Biology
- Physics
Background:
- Terahertz spectroscopy, initially developed by physicists and engineers, is becoming more accessible due to commercial spectrometers.
- Its unique ability to probe intermolecular bonding and crystalline matter makes it highly relevant to chemical analysis.
Purpose of the Study:
- To introduce terahertz spectroscopy to chemists, materials scientists, and biologists.
- To cover techniques, equipment, current applications, and future potential in chemical sciences.
Main Methods:
- This review focuses on explaining the principles and applications of terahertz spectroscopy.
- It details the instrumentation and methodologies involved in terahertz spectroscopic analysis.
Main Results:
- Terahertz spectroscopy provides valuable insights into molecular interactions and solid-state properties.
- The increasing availability of commercial instruments facilitates its adoption across scientific disciplines.
Conclusions:
- Terahertz spectroscopy is a powerful analytical tool with significant potential for the chemical sciences.
- Its application can enhance the understanding of molecular and material properties.
Related Concept Videos
NMR Spectroscopy: Chemical Shift Overview
For instance, the proton...
Atomic Spectroscopy: Absorption, Emission, and Fluorescence
2D NMR: Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC)
UV–Vis Spectroscopy: Molecular Electronic Transitions
Tandem Mass Spectrometry
2D NMR: Overview of Heteronuclear Correlation Techniques

