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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
Published on: May 9, 2025
Nevirapine extended-release for the treatment of HIV-1 infection
1Med. Klinik und Poliklinik, University Hospital of Munich, Downtown Campus, Department of Infectious Diseases, Pettenkoferstr. 8a, D-80336 Munich, Germany. johannes.bogner@med.uni-muenchen.de
Abstract:
Non-nucleoside antiretroviral combination therapy is the standard of care with a robust virologic efficacy and a good safety profile. One of the most frequently used non-nucleosides, nevirapine (NVP), has been available as a every 12 h, immediate-release (IR) tablet since 1996. In order to enhance convenience and adherence, a new pharmaceutical formulation was devised for once-daily use. This is the NVP extended-release (XR) tablet containing 400 mg of NVP. Preclinical and clinical studies were performed to establish the optimal pharmaceutical release form and to establish data on comparability with the conventional NVP-IR. The VERXVE study has shown noninferiority of the new NVP-XR formulation in treatment-naive patients. Safety and tolerability was found to be at least as good as with NVP-IR. NVP-XR is likely to become a convenient treatment option in first-line therapy and will also be a welcome alternative to patients already on NVP.
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